After delving back into the wonderfully frustrating and misinformation-filled world of HSDD medications, it looks like it’s not just Addyi that has new updates. It’s also probably a good time to start keeping a closer eye on Bremelanotide / Vyleesi, a new proposed treatment for HSDD from AMAG Pharmaceuticals.
Unlike Addyi, Bremelanotide is designed to be used only as needed, about 90 min prior to sex. It’s currently being developed to be injected subcutaneously, after other methods showed too many side effects, in particular with worries about low blood pressure. Other common side effects were nausea, flushing, and headaches, which are sure to put you in the mood!
I haven’t had a chance to dig into the proposed method of action, but news articles seem to indicate that it’s neurological, and attempts to balance inhibitory vs. excitatory process in the brain.
It looks like it’s been submitted for new drug consideration by the FDA with an original expected approval announcement in March 2019, but is likely being delayed after the FDA requested more data on side effects.
They’ve also already set up their own website about HSDD as well at unblush.com. It even has it’s own quiz!
I’ve only spent like 20 minutes looking at it so far because I really need to pace myself with these, but here’s a few first impressions:
- If you indicate no recent drop in desire in the first question of the quiz, it cuts you off and lets you know that if there’s no decrease, it’s probably not HSDD – which is more than the addyi site is willing to do, so there’s that at least?
- On the other hand, if you indicate that your desire has decreased “maybe a little”, but in the questions about negative impact you only mark “I’m afraid my partner will cheat on or break up with me”….it tells you that’s “relationship impact”, a sign of HSDD.
- Also, this quiz is like a buzfeed quiz, it’s weirdly full of reaction images and gifs
- Both this and some of the ancillary materials for Addyi mention the Decreased Sexual Desire Screener (DSDS), so that’s something I probably want to look into more when I can.
- Overall, it’s still manipulative / kinda misleading, but doesn’t seem to be quite as pushy as the addyi site overall – but on the other hand they may just be biding their time because they don’t actually have a drug they can legally push yet.